Analyzing the unperturbed HIV-1 T cell reservoir

Brianna Lopez; Robert F Siliciano

doi:10.1016/j.it.2023.01.007

Analyzing the unperturbed HIV-1 T cell reservoir

Trends Immunol. 2023 Mar;44(3):147-149. doi: 10.1016/j.it.2023.01.007. Epub 2023 Feb 2.

Authors

Brianna Lopez¹, Robert F Siliciano²

Affiliations

¹ Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Johns Hopkins University School of Medicine, Baltimore, MD, USA; Howard Hughes Medical Institute, Baltimore, MD, USA. Electronic address: rsiliciano@jhmi.edu.

PMID: 36739207
DOI: 10.1016/j.it.2023.01.007

Abstract

The latent reservoir for HIV-1 prevents cure but is difficult to characterize due to the low frequency of latently infected cells and the absence of unique markers. Sun et al. used single cell analysis of T cell surface phenotypes to provide evidence for immune selection of reservoir cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CD4-Positive T-Lymphocytes
HIV Infections*
HIV-1*
Humans
Virus Latency
Virus Replication