Prognostic significance of natural products against multidrug tumor resistance

Pankaj Garg; Rachana Garg; David Horne; Sanjay Awasthi; Ravi Salgia; Sharad S Singhal

doi:10.1016/j.canlet.2023.216079

Prognostic significance of natural products against multidrug tumor resistance

Cancer Lett. 2023 Mar 31:557:216079. doi: 10.1016/j.canlet.2023.216079. Epub 2023 Feb 2.

Authors

Pankaj Garg¹, Rachana Garg², David Horne³, Sanjay Awasthi⁴, Ravi Salgia⁵, Sharad S Singhal⁶

Affiliations

¹ Department of Chemistry, GLA University, Mathura, Uttar Pradesh, 281406, India.
² Department of Surgery, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA.
³ Department of Molecular Medicine, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA.
⁴ Cayman Health, CTMH Doctors Hospital, George Town, Grand Cayman, KY1-1104, Cayman Islands.
⁵ Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA.
⁶ Department of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA. Electronic address: ssinghal@coh.org.

PMID: 36736532
DOI: 10.1016/j.canlet.2023.216079

Abstract

Cancer is a pervasive, constantly evolving, and significant public health concern. The number of new cancer cases has risen dramatically in the last decades, making it one of the top causes of poor health and mortality worldwide. Although various treatment strategies, including surgery, radiation, and pharmaceutical therapies, have evolved into more sophisticated, precise methods, there is not much improvement in the cancer-related death toll. Consequently, natural product-based therapeutic discoveries have recently been considered an alternative approach. According to an estimate, one-third of the top twenty medications in today's market have a natural plant-product-based origin. Accordingly, primary prevention is an essential component of worldwide cancer control. This review provides an overview of the mechanisms of action of bioactive ingredients in natural dietary products that may contribute to the prevention and management of multiple malignancies.

Keywords: Chemoprevention; Chemotherapeutic drugs; Drug resistance; Natural products.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biological Products* / therapeutic use
Humans
Neoplasms* / drug therapy
Prognosis

Substances

Biological Products