Ionic liquid as hydrogen bond acceptor in the extraction of nutritional natural products

Zhixin Xiao; Min Liu; Wentao Bi; David Da Yong Chen

doi:10.1016/j.foodchem.2023.135589

Ionic liquid as hydrogen bond acceptor in the extraction of nutritional natural products

Food Chem. 2023 Jun 30:412:135589. doi: 10.1016/j.foodchem.2023.135589. Epub 2023 Jan 27.

Authors

Zhixin Xiao¹, Min Liu¹, Wentao Bi², David Da Yong Chen³

Affiliations

¹ Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China.
² Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China. Electronic address: biwentao@njnu.edu.cn.
³ Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China; Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada. Electronic address: chen@chem.ubc.ca.

PMID: 36736187
DOI: 10.1016/j.foodchem.2023.135589

Abstract

In-depth studies of the extraction mechanism using deep eutectic solvents (DES), especially extraction through the formation of a deep eutectic system (DESys), revealed commonalities between the DES- and ionic liquids (IL)-based extraction systems. New applications of ILs and DES for extraction of nutritional natural products were presented. In this study, the extraction behavior of choline chloride (ChCl) and 1-(2-hydroxyethyl)-3-methylimidazolium chloride ([HMIm][Cl]) in DES and IL, respectively, in mechanochemical extraction of target compounds from Moringa oleifera leaves was systematically studied. The results suggested that both extraction methods were based on the formation of a DESys, either a normal DESys or an IL DESys. Considering the DESys-based one-step extraction improves the extraction efficiency and reduces the preparation time, the same idea can be used in IL for performance improvement. By formation of a new IL deep eutectic system based on hydrogen bond interaction in extraction, similar improvement was obtained.

Keywords: Deep eutectic solvent; Deep eutectic system; Ionic liquid; Mechanochemical extraction; Natural product.

MeSH terms

Biological Products* / chemistry
Choline / chemistry
Hydrogen Bonding
Ionic Liquids* / chemistry
Solvents / chemistry

Substances

Ionic Liquids
Solvents
Biological Products
Choline