Evaluation of cell adhesion and osteoconductivity in bone substitutes modified by polydopamine

Ali Mahnavi; Mina Shahriari-Khalaji; Bahareh Hosseinpour; Mostafa Ahangarian; Amir Aidun; Simona Bungau; Syed Shams Ul Hassan

doi:10.3389/fbioe.2022.1057699

Evaluation of cell adhesion and osteoconductivity in bone substitutes modified by polydopamine

Front Bioeng Biotechnol. 2023 Jan 13:10:1057699. doi: 10.3389/fbioe.2022.1057699. eCollection 2022.

Authors

Ali Mahnavi¹, Mina Shahriari-Khalaji², Bahareh Hosseinpour³, Mostafa Ahangarian¹, Amir Aidun^{4

5}, Simona Bungau⁶, Syed Shams Ul Hassan^{7

8}

Affiliations

¹ Department of Biomaterials, Faculty of Interdisciplinary Science and Technology, Tarbiat Modares University, Tehran, Iran.
² State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, China.
³ Department of Chemistry, Carleton University, Ottawa, ON, Canada.
⁴ National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
⁵ Tissues and Biomaterials Research Group (TBRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁶ Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
⁷ Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
⁸ Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.

Abstract

Bones damaged due to disease or accidents can be repaired in different ways. Tissue engineering has helped with scaffolds made of different biomaterials and various methods. Although all kinds of biomaterials can be useful, sometimes their weakness in cellular activity or osteoconductivity prevents their optimal use in the fabrication of bone scaffolds. To solve this problem, we need additional processes, such as surface modification. One of the common methods is coating with polydopamine. Polydopamine can not only cover the weakness of the scaffolds in terms of cellular properties, but it can also create or increase osteoconductivity properties. Polydopamine creates a hydrophilic layer on the surface of scaffolds due to a large number of functional groups such as amino and hydroxyl groups. This layer allows bone cells to anchor and adheres well to the surfaces. In addition, it creates a biocompatible environment for proliferation and differentiation. Besides, the polydopamine coating makes the surfaces chemically active by catechol and amine group, and as a result of their presence, osteoconductivity increases. In this mini-review, we investigated the characteristics, structure, and properties of polydopamine as a modifier of bone substitutes. Finally, we evaluated the cell adhesion and osteoconductivity of different polydopamine-modified bone scaffolds.

Keywords: biomaterials; bone; cell adhesion; osteoconductivity; polydopamine; scaffold; surface modification; tissue engineering.

Publication types

Review

Grants and funding

The APC was funded by the University of Oradea, and the research was funded by the Romanian Ministry of Research, Innovation, and Digitization through Program 1-Development of the National Research and Development System, Subprogram 1.2—Institutional Performance Projects for funding the excellence in RDI, Contract No. 29 PFE/30.12.2021 with the University of Oradea, Oradea, Romania.