Efficacy on gait and posture control after botulinum toxin A injection for lower-limb spasticity treatment after stroke: A randomized controlled trial

Hui-Xian Yu; Si-Hao Liu; Zhao-Xia Wang; Chang-Bin Liu; Pei Dai; Da-Wei Zang

doi:10.3389/fnins.2022.1107688

Efficacy on gait and posture control after botulinum toxin A injection for lower-limb spasticity treatment after stroke: A randomized controlled trial

Front Neurosci. 2023 Jan 16:16:1107688. doi: 10.3389/fnins.2022.1107688. eCollection 2022.

Authors

Hui-Xian Yu¹, Si-Hao Liu¹, Zhao-Xia Wang¹, Chang-Bin Liu¹, Pei Dai¹, Da-Wei Zang¹

Affiliation

¹ Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Abstract

Objectives: To observe the efficacy of botulinum toxin type A (BoNT-A) for the spasticity of the lower-limb post-stroke on gait and posture control.

Methods: A total of 46 patients with hemiplegia gait were randomly divided into the experimental group (23 patients) and the control group (23 patients). In patients in the experimental group received injections of BoNT-A by electrical stimulation-guided. At the same time, patients of the two groups received routine physical therapy. Gait analysis, plantar pressure analysis, lower-limb Fugl-Meyer assessment (L-FMA), 10 meter walking test (10MWT), timed "Up and Go" test (TUGT), and modified Ashworth Scale assess (MAS) of the lower limbs were performed at 0, 1, 4, and 12 weeks after treatment.

Results: At 1, 4, and 12 weeks after treatment, the L-FMA, stride length, speed, and TUGT significantly improved than 0 week in both groups. The L-FMA and peak of forefoot pressure, and MAS results in the experimental group were better than those in the control group at 4 and 12 weeks. The TUGT, speed, and stride length in experimental group was significantly shortened than that in control group at 1, 4, and 12 weeks.

Conclusion: Botulinum toxin type A injection can improve motor functions of the lower limb, gait, spasticity, forefoot pressure, and posture control of patients after stroke.

Keywords: botulinum toxin A; gait; posture control; spasticity; stroke.

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (Grant Numbers: 82072532 and 82000723) and National Natural Science Foundation of Capital Medical University (Grant Number: XZR2021-114).