Relation between semen oxidative reduction potential in initial semen examination and IVF outcomes

Kazuhisa Tomita; Kankanam Gamage Sanath Udayanga; Manabu Satoh; Shu Hashimoto; Yoshiharu Morimoto

doi:10.1002/rmb2.12501

Relation between semen oxidative reduction potential in initial semen examination and IVF outcomes

Reprod Med Biol. 2023 Jan 28;22(1):e12501. doi: 10.1002/rmb2.12501. eCollection 2023 Jan-Dec.

Authors

Kazuhisa Tomita¹, Kankanam Gamage Sanath Udayanga¹, Manabu Satoh^{1

2}, Shu Hashimoto³, Yoshiharu Morimoto¹

Affiliations

¹ HORAC Grand Front Osaka Clinic Osaka Japan.
² IVF Namba Clinic Osaka Japan.
³ Osaka Metropolitan University Graduate School of Medicine Osaka Japan.

Abstract

Purpose: The MiOXSYS system is a new technique to analyze the semen oxidative reduction potential (ORP) that may use to classify the level of sperm DNA integrity. It does not clearly explain how the semen ORP values could help to change the IVF outcomes. We have analyzed correlations between semen ORP value and the IVF results.

Methods: Four hundred and thirty couples were enrolled. The male counterparts were divided into two groups according to their semen ORP values and compared the fertilization rate, cell cleavage rate, and embryo quality, following the IVF procedures. The relations between ORP values and the clinical pregnancy, live birth, and abortion rates were analyzed.

Results: The ORP values show negative and positive correlations with some conventional semen parameters. The fertilization and the cleavage rate did not show any differences in those two groups, but the transferable embryo rate was significantly high in patients with high semen ORP. However, the patients with high ORP show a tendency to lower clinical pregnancy with a low abortion rate compared to the low ORP group.

Conclusion: The main purpose of measuring the ORP value in semen is still questionable and shows controversial results.

Keywords: in vitro fertilization outcome; oxidative reduction potential; oxidative stress; semen.