A Perspective on Bone Morphogenetic Proteins: Dilemma behind Cancer- related Responses

Curr Drug Targets. 2023;24(5):382-387. doi: 10.2174/1389450124666230201144605.

Abstract

Bone morphogenetic proteins are a center of serious concern and are known to execute various cancer-related issues. The BMP signaling cascades have become more unpredictable as a result of their pleiotropic and risky characteristics, particularly when it comes to cancer responses. This perspective discusses the current therapeutic implications, emphasizes different cellular aspects that impact the failures of the current drug treatments, and speculates on future research avenues that include novel strategies like metabolomic studies and bio-mimetic peptide therapeutics to mitigate cancerous outcomes.

Keywords: BMP signaling; Bone morphogenetic proteins (BMPs); bio-mimetic peptide; cancer; dual behavior; signaling cascades.

MeSH terms

  • Bone Morphogenetic Proteins / metabolism
  • Humans
  • Neoplasms* / drug therapy
  • Signal Transduction / physiology
  • Transforming Growth Factor beta* / metabolism

Substances

  • Transforming Growth Factor beta
  • Bone Morphogenetic Proteins