Clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteraemia

Eur J Clin Microbiol Infect Dis. 2023 Mar;42(3):379-382. doi: 10.1007/s10096-023-04559-z. Epub 2023 Feb 2.

Abstract

This retrospective study, conducted at Lausanne University Hospital (2015-2021), compared Staphylococcus aureus bacteraemia (SABA) patients with or without concomitant bacteriuria (SABU). Among 448 included bacteraemic patients, 62 (13.8%) had S. aureus concurrently isolated from urine. In multivariate analysis, there was a significant difference in the odds of community-onset bacteraemia (P 0.030), malignancy (P 0.002), > 1 pair of positive blood cultures (P 0.037), and persistent bacteraemia for at least 48 h (P 0.045) in patients with concurrent SABU. No difference concerning mortality was found. On the other hand, SABU was associated with higher rates of SABA recurrence after antibiotic cessation.

Keywords: Bacteraemia; Bacteriuria; Bloodstream infection; Infective endocarditis; Staphylococcus aureus.

MeSH terms

  • Bacteremia* / complications
  • Bacteremia* / microbiology
  • Bacteriuria* / complications
  • Bacteriuria* / microbiology
  • Clinical Relevance
  • Humans
  • Retrospective Studies
  • Staphylococcal Infections* / complications
  • Staphylococcal Infections* / microbiology
  • Staphylococcus aureus