Copper-Catalyzed Aerobic C(sp3)-H Oxidation of β-(Alkoxy)imino Carbonyl Compounds

Masafumi Ueda; Ayano Ichimonji; Miku Nakayama; Sachiko Ito; Norihiko Takeda; Motohiro Yasui

doi:10.1248/cpb.c22-00403

Copper-Catalyzed Aerobic C(sp³)-H Oxidation of β-(Alkoxy)imino Carbonyl Compounds

Chem Pharm Bull (Tokyo). 2023;71(2):83-92. doi: 10.1248/cpb.c22-00403.

Authors

Masafumi Ueda¹, Ayano Ichimonji¹, Miku Nakayama¹, Sachiko Ito¹, Norihiko Takeda¹, Motohiro Yasui¹

Affiliation

¹ Kobe Pharmaceutical University.

PMID: 36724984
DOI: 10.1248/cpb.c22-00403

Abstract

Direct oxidation of the C(sp³)-H bond of β-(alkoxy)imino carbonyl compounds using copper acetate and molecular oxygen has been established. The protocol features a broad substrate scope and generates 1-imino-2,3-dicarbonyls in good to excellent yields.

Keywords: C–H oxidation; aerobic oxidation; copper catalyst; β-imino carbonyl compound.

MeSH terms

Alcohols* / chemistry
Catalysis
Copper* / chemistry
Molecular Structure

Substances

alkoxyl radical
Copper
Alcohols