Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

Laura Rijns; Lu Su; Konrad Maxeiner; Giulia Morgese; David Y W Ng; Tanja Weil; Patricia Y W Dankers

doi:10.1039/d2cc06064g

Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels

Chem Commun (Camb). 2023 Feb 16;59(15):2090-2093. doi: 10.1039/d2cc06064g.

Authors

Laura Rijns^{1

2

3}, Lu Su⁴, Konrad Maxeiner⁵, Giulia Morgese⁶, David Y W Ng⁵, Tanja Weil⁵, Patricia Y W Dankers^{1

2

3}

Affiliations

¹ Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands. p.y.w.dankers@tue.nl.
² Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands.
³ Department of Biomedical Engineering, Laboratory for Cell and Tissue Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands.
⁴ Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands. l.su@lacdr.leidenuniv.nl.
⁵ Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany.
⁶ ZHAW Zurich University of Applied Sciences, School of Engineering, Forschungsbereich Polymere Beschichtungen, Technikumstrasse 9, Winterthur 8400, Switzerland.

Abstract

Benzene-1,3,5-tricarboxamide (BTA) glyco-monomers containing one, two or three mannose units are synthesized and formulated into differently patterned supramolecular glycopolymers through homo-assembly or co-assembly with non-functionalized BTAs. Unfortunately, no cellular activity could be detected. Excitingly, these glyco-BTA monomers could be formulated into hydrogels, paving the way for (immune) cell culture.

MeSH terms

Hydrogels*
Mannose*

Substances

Mannose
Hydrogels