Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1

Sodiq O Waheed; Ann Varghese; Isabella DiCastri; Brenden Kaski; Ciara LaRouche; Gregg B Fields; Tatyana G Karabencheva-Christova

doi:10.1002/cphc.202200943

Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1

Chemphyschem. 2023 Feb 1;24(3):e202200943. doi: 10.1002/cphc.202200943.

Authors

Sodiq O Waheed¹, Ann Varghese¹, Isabella DiCastri¹, Brenden Kaski², Ciara LaRouche³, Gregg B Fields⁴, Tatyana G Karabencheva-Christova¹

Affiliations

¹ Department of Chemistry, Michigan Technological University, Houghton, Michigan, 49931, USA.
² Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan, 49931, USA.
³ Department of Chemical Engineering, Michigan Technological University, Houghton, Michigan, 49931, USA.
⁴ Department of Chemistry & Biochemistry and I-HEALTH, Florida Atlantic University, Jupiter, Florida, 33458, USA.

PMID: 36723036
DOI: 10.1002/cphc.202200943

Abstract

The front cover artwork is provided by Dr. Karabencheva-Christova's group at Michigan Technological University. The images show the initially formed and the catalytically productive conformations of MMP-1 complex with the Triple Helical Peptide (THP), the free energy profile connecting them as well as the coordination geometry of the catalytic zinc (II). The background shows the collagen macromolecule. Read the full text of the Research Article at 10.1002/cphc.202200649.