Inorganic nanodendrites (NDs) have become a kind of advanced nanomaterials with broad application prospects because of their unique branched architecture. The structural characteristics of nanodendrites include highly branched morphology, abundant tips/edges and high-index crystal planes, and a high atomic utilization rate, which give them great potential for usage in the fields of electrocatalysis, sensing, and therapeutics. Therefore, the rational design and controlled synthesis of inorganic (especially noble metals) nanodendrites have attracted widespread attention nowadays. The development of synthesis strategies and characterization methodology provides unprecedented opportunities for the preparation of abundant nanodendrites with interesting crystallographic structures, morphologies, and application performances. In this review, we systematically summarize the formation mechanisms of noble metal nanodendrites reported in recent years, with a special focus on surfactant-mediated mechanisms. Some typical examples obtained by innovative synthetic methods are then highlighted and recent advances in the application of noble metal nanodendrites are carefully discussed. Finally, we conclude and present the prospects for the future development of nanodendrites. This review helps to deeply understand the synthesis and application of noble metal nanodendrites and may provide some inspiration to develop novel functional nanomaterials (especially electrocatalysts) with enhanced performance.