Lodopyridones D - G from a marine-derived bacterium Saccharomonospora sp

Prima F Hillman; Ji Young Lee; Juri Lee; Jihye Lee; Dong-Chan Oh; William Fenical; Sang-Jip Nam

doi:10.1080/14786419.2023.2173192

Lodopyridones D - G from a marine-derived bacterium Saccharomonospora sp

Nat Prod Res. 2023 Jan 30:1-6. doi: 10.1080/14786419.2023.2173192. Online ahead of print.

Authors

Prima F Hillman¹, Ji Young Lee¹, Juri Lee¹, Jihye Lee^{1

2}, Dong-Chan Oh³, William Fenical⁴, Sang-Jip Nam¹

Affiliations

¹ Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Republic of Korea.
² Laboratories of Marine New Drugs, REDONE SEOUL, Seoul, Republic of Korea.
³ Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
⁴ Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.

PMID: 36714927
DOI: 10.1080/14786419.2023.2173192

Abstract

The intensive investigation of chemical components from the culture broth of the bacterium Saccharomonospora sp. CNQ-490 has yielded four new natural products, lodopyridones D - G (1 - 4) along with the previously reported compounds, lodopyridones A - C (5 - 7) and cotteslosin A (8). The planar structures of the lodopyridones D - G (1 - 4) were elucidated by interpreting the mass spectrometry, ultraviolet (UV) spectroscopy, and 1D and 2D nuclear magnetic spectroscopy (NMR) data, as well as comparing NMR data with those of the lodopyridones A - C (5 - 7).

Keywords: HPLC-UV guided fractionation; Saccharomonospora sp.; lodopyridones D − G; marine-derived bacterium.