Association between triglyceride glucose index and risk of cancer: A meta-analysis

Huan Wang; Feifei Yan; Yani Cui; Feinan Chen; Guixia Wang; Weiwei Cui

doi:10.3389/fendo.2022.1098492

Association between triglyceride glucose index and risk of cancer: A meta-analysis

Front Endocrinol (Lausanne). 2023 Jan 12:13:1098492. doi: 10.3389/fendo.2022.1098492. eCollection 2022.

Authors

Huan Wang¹, Feifei Yan², Yani Cui², Feinan Chen², Guixia Wang¹, Weiwei Cui²

Affiliations

¹ Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun, China.
² Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China.

Abstract

Background: Triglyceride glucose (TyG) index as a more convenient and reliable predictor of insulin resistance (IR) is thought to be associated with many diseases, but its relationship with cancer remains unclear.

Methods: The meta-analysis was conducted to evaluate the effects of TyG index on cancer risk utilizing the available evidence. PubMed, EMBASE, Medline, Cochrane Library and Web of Science were searched from their inception up to July 2022. A random-effects model was used to calculate the effect estimates and 95% confidence intervals (CIs).

Results: A total of 6 observational studies met our inclusion criteria, which including 992292 participants. The meta-analysis indicated that the higher TyG index increased cancer risk compared to the lower TyG index group (total effect size =1.14, 95% CI [1.08, 1.20], P<0.001).

Conclusions: Our meta-analysis found that higher TyG index may increase the risk of cancer. More prospective cohort studies and basic research are warranted to verify the relationship.

Keywords: cancer; meta-analysis; observational research; random effects model; triglyceride glucose index.

Publication types

Meta-Analysis

MeSH terms

Glucose
Humans
Insulin Resistance*
Neoplasms* / epidemiology
Neoplasms* / etiology
Prospective Studies
Triglycerides

Substances

Glucose
Triglycerides