Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals

Manman Qin; Yuqing Qian; Lu Huang; Chao Zhong; Mingdong Li; Jun Yu; Huanwen Chen

doi:10.3389/fphar.2023.1110900

Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals

Front Pharmacol. 2023 Jan 13:14:1110900. doi: 10.3389/fphar.2023.1110900. eCollection 2023.

Authors

Manman Qin^{1

2

3}, Yuqing Qian⁴, Lu Huang⁴, Chao Zhong^{2

3}, Mingdong Li⁴, Jun Yu⁵, Huanwen Chen¹

Affiliations

¹ Mass Spectrometry Laboratory for BioSample Analysis, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
² Key Laboratory for Pharmacology and Translational Research of Traditional Chinese Medicine of Nanchang, Centre for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
³ Jiangxi Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Vascular Remodeling Diseases, Nanchang, Jiangxi, China.
⁴ School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
⁵ Department of Cardiovascular Sciences and Centre for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

Abstract

Extraction electrospray ionization mass spectrometry (EESI-MS), due to the unique configuration of its ionization module, enables the effective ionization of trace molecules of interest in samples containing complex matrices with high sensitivity, high selectivity and high responding speed without requiring sample pretreatment, and allows high-energy molecular species to undergo specially designed reactions for advanced functionalization. The typical effects of operating conditions on the analytical performance of extraction electrospray ionization mass spectrometry for various pharmaceutical compounds, pharmaceutical preparations and herbal materials were systematically reviewed. The application prospect of extraction electrospray ionization in molecular functionalization for advanced drug discovery is also briefly introduced.

Keywords: analytical evaluation; extractive electrospray ionization mass spectrometry; internal extractive electrospray ionization mass spectrometry; neutral-desorption extractive electrospray ionization mass spectrometry; pharmaceutical chemicals; synthetic preparation.

Publication types

Review

Grants and funding

This work was supported by the Scientific Research Foundation of the Education Department of Jiangxi province (GJJ201270); Science and Technology Program of the Department of Jiangxi Administration of Traditional Chinese Medicine (2021A394); Jiangxi University of Chinese Medicine School-level Science and Technology Innovation Team Development Program (CXTD22005); High-level Talents Project of First-class Discipline of Traditional Chinese Medicine (13030599); Jiangxi Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Vascular Remodel-ing Diseases (20202BCD42014); National Natural Science Foundation of China (82104180); Jiangxi Provincial Natural Science Foundation (20212BAB216012).