Research progress on the role and mechanism of miR-671 in bone metabolism and bone-related diseases

Shaotai Wang; Min Hu; Dongsheng Song; Linjun Tang; Huan Jiang

doi:10.3389/fonc.2022.1018308

Research progress on the role and mechanism of miR-671 in bone metabolism and bone-related diseases

Front Oncol. 2023 Jan 11:12:1018308. doi: 10.3389/fonc.2022.1018308. eCollection 2022.

Authors

Shaotai Wang^{1

2}, Min Hu^{1

2}, Dongsheng Song^{1

2}, Linjun Tang¹, Huan Jiang^{1

2}

Affiliations

¹ Department of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, China.
² Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun, China.

Abstract

Bone metabolism consists of bone formation and resorption and maintains a dynamic balance in vivo. When bone homeostasis is broken, it can manifest as osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), etc. MiR-671, an important class of non-coding nucleotide sequences in vivo, is regulated by lncRNA and regulates bone metabolism balance by regulating downstream target proteins and activating various signaling pathways. Based on the structure and primary function of miR-671, this paper summarizes the effect and mechanism of miR-671 in bone-related inflammation and cancer diseases, and prospects the application possibility of miR-671, providing reference information for targeted therapy of bone-related disorders.

Keywords: bone metabolism; cancer; inflammation; lncRNA; miR-671.

Publication types

Review

Grants and funding

The study is partly supported by the National Natural Science Foundation of China (No.81870795), the Finance department Project of Jilin Province (JCSZ2019378-19), and the National Science Foundation of Jilin Province (20200201348JC).