Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH

Md Khadem Ali; Lan Zhao; Vinicio de Jesus Perez; Mark R Nicolls; Edda F Spiekerkoetter

doi:10.1101/2023.01.14.524023

Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH

bioRxiv [Preprint]. 2023 Jan 16:2023.01.14.524023. doi: 10.1101/2023.01.14.524023.

Authors

Md Khadem Ali^{1

2}, Lan Zhao^{1

2}, Vinicio de Jesus Perez^{1

2}, Mark R Nicolls^{1

2}, Edda F Spiekerkoetter^{1

2}

Affiliations

¹ Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.
² Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University, Stanford, CA, USA.

Abstract

ELK3 is upregulated in blood and pulmonary vascular cells of PAH patients and may play a significant role in PAH potentially through modulating BMPR2 signaling.

Publication types

Preprint

Abstract

Publication types

Grants and funding