Dynamic crosstalk between hematopoietic stem cells and their niche from emergence to aging

Abstract

The behavior of somatic stem cells is regulated by their niche. Interaction between hematopoietic stem cells (HSCs) and their niches are a representative model to understand stem cell-niche interplay. Here, we provide an overview of crosstalk between HSCs and their niches in bone marrow and extramedullary organs following the life journey of HSCs from emergence, development, maturation until aging. We highlight the unique differences of HSC niches in different life stages within various organs focusing on recent literature to propose new speculations and hypotheses.

Keywords: bone marrow; extramedullary niche; hematopoietic stem cell; neuromodulator; perivascular cell; stem cell niche; vascular endothelial cell.