Mitochondrial dysfunction and oxidative stress: Role in chronic kidney disease

Life Sci. 2023 Apr 15:319:121432. doi: 10.1016/j.lfs.2023.121432. Epub 2023 Jan 24.

Abstract

Chronic kidney disease (CKD) is associated with a variety of distinct disease processes that permanently change the function and structure of the kidney across months or years. CKD is characterized as a glomerular filtration defect or proteinuria that lasts longer than three months. In most instances, CKD leads to end-stage kidney disease (ESKD), necessitating kidney transplantation. Mitochondrial dysfunction is a typical response to damage in CKD patients. Despite the abundance of mitochondria in the kidneys, variations in mitochondrial morphological and functional characteristics have been associated with kidney inflammatory responses and injury during CKD. Despite these variations, CKD is frequently used to define some classic signs of mitochondrial dysfunction, including altered mitochondrial shape and remodeling, increased mitochondrial oxidative stress, and a marked decline in mitochondrial biogenesis and ATP generation. With a focus on the most significant developments and novel understandings of the involvement of mitochondrial remodeling in the course of CKD, this article offers a summary of the most recent advances in the sources of procured mitochondrial dysfunction in the advancement of CKD. Understanding mitochondrial biology and function is crucial for developing viable treatment options for CKD.

Keywords: Chronic kidney disease; Inflammation; Mitochondrial dysfunction; Oxidative stress; ROS.

Publication types

  • Review

MeSH terms

  • Humans
  • Kidney / metabolism
  • Kidney Failure, Chronic*
  • Mitochondria / metabolism
  • Oxidative Stress
  • Renal Insufficiency, Chronic*