Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

Jicheng Han; Xiangyu Zhu; Zihan Gao; Yan Xiao; Jinxin Zhang; Peng Wang; Jinbo Fang; Yiquan Li; Yilong Zhu; Yue Li; Ningyi Jin; Huijun Lu; Dazhuan Lin; Wenshen Liu

doi:10.3389/fmicb.2022.1067725

Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection

Front Microbiol. 2023 Jan 10:13:1067725. doi: 10.3389/fmicb.2022.1067725. eCollection 2022.

Authors

Jicheng Han^{1

2}, Xiangyu Zhu^{1

3}, Zihan Gao^{1

2}, Yan Xiao^{1

2}, Jinxin Zhang^{1

2}, Peng Wang^{1

3}, Jinbo Fang², Yiquan Li², Yilong Zhu², Yue Li^{1

2}, Ningyi Jin^{1

2}, Huijun Lu¹, Dazhuan Lin⁴, Wenshen Liu¹

Affiliations

¹ Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
² Academician Workstation, Changchun University of Chinese Medicine, Changchun, China.
³ College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
⁴ College of Pharmaceuticals and Food, Changchun Medical College, Changchun, China.

Abstract

Influenza viruses pose a serious threat to human health, infecting hundreds of millions of people worldwide each year, resulting in a significant increase in global morbidity and mortality. Influenza activity has declined at the onset of the COVID-19 pandemic, but the genetic diversity of B/Victoria lineage viruses has increased significantly during this period. Therefore, the prevention and treatment of the influenza B Victoria strain virus should continue to attract research attention. In this study, we found that Atractyloside A (AA), one of the effective components in Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study shows that AA not only possesses anti-influenza B virus infection effects in vivo and in vitro but also can regulate macrophage polarization to the M2 type, which can effectively attenuate the damage caused by influenza B virus infection. Therefore, Atractyloside A may be an effective natural drug against B/Victoria influenza infection.

Keywords: Atractyloside A; antiviral drugs; influenza B virus (IBV); influenza virus; macrophage polarization.

Grants and funding

This study was supported by the Changchun Science and Technology Development Project [Grant No. 21ST03], the Jilin Province Traditional Chinese Medicine Science and Technology Project [Grant No. 2022129], the Jilin Province Young Science and Technology Talent Support Project [Grant No. QT202228], and the China Postdoctoral Science Foundation [Grant No. 2022M713867].