Extracellular protein degradation via the lysosome

Mohamed A Eldeeb; Cornelia E Zorca; Thomas Goiran

doi:10.1038/s42004-020-00397-8

Extracellular protein degradation via the lysosome

Commun Chem. 2020 Oct 30;3(1):149. doi: 10.1038/s42004-020-00397-8.

Authors

Mohamed A Eldeeb^#¹, Cornelia E Zorca^#², Thomas Goiran^#²

Affiliations

¹ Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. Mohamed.eldeeb@mcgill.ca.
² Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

^# Contributed equally.

Abstract

Tight regulation of protein levels is so crucial for cellular function that mammalian cells have evolved two parallel degradation systems. This article discusses how these systems can be exploited to selectively target proteins of interest for therapeutic purposes.