The presence of the ultramicroelement Se in food is irreplaceable. Se is a component of more than 30 biologically active compounds found in humans and animals. Se levels less than 1 mg/kg have been found to be beneficial to plants. Radish is one of the most commonly cultivated vegetables worldwide and is rich in bioactive substances, vitamins, enzymes, and minerals. Radish increases resistance and protects the human body from a number of diseases, particularly diabetes, cardiovascular, and gastrointestinal diseases. The physiological multifunctional (anti-diabetic, antioxidant, and anti-inflammatory) activity of the Se-enriched plant material was also studied. This is of practical significance because the data obtained can be the basis for the development of biotechnology for the enrichment of vegetable plants with Se.