Study of the clinicopathological features of soluble PD-L1 in lung cancer patients

Takanobu Sasaki; Ryo Nonomura; Toshiharu Tabata; Naruo Yoshimura; Shuko Hata; Hiroki Shimada; Yasuhiro Nakamura

doi:10.2185/jrm.2022-040

Study of the clinicopathological features of soluble PD-L1 in lung cancer patients

J Rural Med. 2023 Jan;18(1):42-49. doi: 10.2185/jrm.2022-040. Epub 2023 Jan 6.

Authors

Takanobu Sasaki^{1

2}, Ryo Nonomura¹, Toshiharu Tabata¹, Naruo Yoshimura³, Shuko Hata⁴, Hiroki Shimada⁴, Yasuhiro Nakamura⁴

Affiliations

¹ Department of Thoracic Surgery, Tohoku Medical and Pharmaceutical University, Japan.
² Department of Public health, graduate school of medicine, Tohoku University, Japan.
³ Department of Respirology, Tohoku Medical and Pharmaceutical University, Japan.
⁴ Division of Pathology, Tohoku Medical and Pharmaceutical University, Japan.

Abstract

Objective: In recent years, an association between serum soluble immune checkpoint molecules (sICMs) and malignant tumors has been reported, which may become important biomarkers in the future. Although several reports have suggested a correlation between sICMs and prognosis, their origin is unclear. In this study, changes in serum soluble PD-L1 (sPD-L1) during the perioperative period and its origin were analyzed in patients with lung cancer. Patients and Methods: Patients with lung tumors (n=39) were included. Samples for sPD-L1 measurements were collected at five time points before and after surgery, and their changes over time were analyzed. ELISA was used to measure sPD-L1 levels. Results: Thirty-nine patients with lung tumors (31, males; 8, females; age, 74 (years) ± 7.7 (range: 51-89) years; malignancy/benign, 33/6) were enrolled. Eight cases of driver gene mutation-positive tumors were included. Twenty-eight (72%) patients were smokers, and their performance status was 0-1 in all 39 patients. PD-L1 TPS was ≥50%/1-49%/<1% in 8/10/14 patients. Stage I/II/III/IV/postoperative recurrence of lung cancer was observed in 21/0/6/5/1 patients, respectively. There were no significant correlations between sPD-L1 levels and clinicopathological features and no correlation with PD-L1 TPS. Comparing localized lesions (stages I-III) with advanced lesions (stage IV and postoperative recurrence), the distribution of sPD-L1 was slightly higher in advanced lesions, although the difference was not significant. No obvious changes in sPD-L1 expression were observed before and after surgery. Conclusion: sPD-L1 levels tended to be high in stage III and above lung cancer. There was no change in sPD-L1 levels before and after surgery. sPD-L1 levels did not correlate with the PD-L1 TPS.