Nitric oxide and thyroid carcinoma: A review

Yu Huang; Rinkiko Suguro; Wei Hu; Jiayu Zheng; Yawen Liu; Mingxin Guan; Na Zhou; Xin Zhang

doi:10.3389/fendo.2022.1050656

Nitric oxide and thyroid carcinoma: A review

Front Endocrinol (Lausanne). 2023 Jan 9:13:1050656. doi: 10.3389/fendo.2022.1050656. eCollection 2022.

Authors

Yu Huang¹, Rinkiko Suguro², Wei Hu², Jiayu Zheng¹, Yawen Liu³, Mingxin Guan⁴, Na Zhou^{1

2}, Xin Zhang^{1

2}

Affiliations

¹ School of Pharmacy, Macau University of Science and Technology, Macau, Macau SAR, China.
² State Key Laboratory of Quality Research in Chinese Medicine, Macau, Macau SAR, China.
³ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
⁴ College of Pharmacy, Dalian Medical University, Dalian, China.

Abstract

Thyroid carcinoma is the most common endocrine cancer in the world, and its incidence has been steadily increasing in recent years. Despite its relatively good prognosis, therapies have not improved greatly in recent years. Therefore, exploring new therapies for thyroid carcinoma represents an unmet need. Nitric oxide (NO) is a short-term endogenous signaling molecule that plays a vital role in various physiological and pathological processes and is synthesized by nitric oxide synthase (NOS). Many studies have been conducted over the past decades to explain its correlation to cancer. NO exerts a wide range of effects on cancer, involving angiogenesis, apoptosis, cell cycle, invasion, and metastasis. It also serves a dual function by promoting and halting tumor development simultaneously. The relationship between NO and thyroid carcinoma has been intensively studied and discussed. This paper reviews the role and molecular mechanism of NO in thyroid carcinoma and discusses potentials of prevention and treatment of thyroid carcinoma.

Keywords: eitric oxide synthase; endocrine system; nitric oxide; thyroid carcinoma; treatment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Humans
Nitric Oxide Synthase / metabolism
Nitric Oxide* / metabolism
Signal Transduction
Thyroid Neoplasms*

Substances

Nitric Oxide
Nitric Oxide Synthase

Grants and funding

This work was supported by the Macau Science and Technology Development fund (FDCT 0088/2021/A、0089/2021/A). The Faculty Research Grants of Macau University of Science and Technology (FRG-21-039、FRG-22-078).