Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems

Hamidreza Garshasbi; Saba Salehi; Seyed Morteza Naghib; Sadegh Ghorbanzadeh; Wei Zhang

doi:10.3389/fbioe.2022.1126774

Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems

Front Bioeng Biotechnol. 2023 Jan 6:10:1126774. doi: 10.3389/fbioe.2022.1126774. eCollection 2022.

Authors

Hamidreza Garshasbi¹, Saba Salehi¹, Seyed Morteza Naghib¹, Sadegh Ghorbanzadeh², Wei Zhang²

Affiliations

¹ Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology and Biomaterials and Tissue Engineering Department, Breast Cancer Research Center, Motamed Cancer Institute, Iran University of Science and Technology (IUST), The Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
² State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China.

Abstract

In the last decade, injectable hydrogels have attracted a lot of attention due to their excellent functional properties in the field of drug delivery for precise, non-invasive and focused tissue locations. Therefore, designing drug delivery systems (DDS) responsive to hydrogel stimuli to release a drug to an external stimulus with various advantages, can be very challenging. Due to their biocompatibility, mucosal adhesion, and hemostatic activity, chitosan (Chitosan)-based hydrogels offer a lot of potential for tissue engineering and drug delivery. It can be difficult to manage the structure of these stimuli-responsive CS hydrogels or they may require additional crosslinking agents, such as hydrogels with dual pH and thermo-responsiveness. Therefore, it is crucial to create these hydrogels for medicinal applications.

Keywords: chitosan; hydrogels; injectable; pH; stimuli-responsive.

Publication types

Review