Positive-strand RNA viruses-a Keystone Symposia report

Jennifer Cable; Mark R Denison; Margaret Kielian; William T Jackson; Ralf Bartenschlager; Tero Ahola; Suchetana Mukhopadhyay; Daved H Fremont; Richard J Kuhn; Ashleigh Shannon; Meredith N Frazier; Kwok-Yung Yuen; Carolyn B Coyne; Katja C Wolthers; Guo-Li Ming; Camy S Guenther; Jasmine Moshiri; Sonja M Best; John W Schoggins; Kellie Ann Jurado; Gregory D Ebel; Alexandra Schäfer; Lisa F P Ng; Marjolein Kikkert; Alessandro Sette; Eva Harris; Peter A C Wing; Julie Eggenberger; Siddharth R Krishnamurthy; Marcus G Mah; Rita M Meganck; Donghoon Chung; Sebastian Maurer-Stroh; Raul Andino; Bette Korber; Stanley Perlman; Pei-Yong Shi; Montserrat Bárcena; Sophie-Marie Aicher; Michelle N Vu; Devin J Kenney; Brett D Lindenbach; Yukiko Nishida; Laurent Rénia; Evan P Williams

doi:10.1111/nyas.14957

Positive-strand RNA viruses-a Keystone Symposia report

Ann N Y Acad Sci. 2023 Mar;1521(1):46-66. doi: 10.1111/nyas.14957. Epub 2023 Jan 25.

Authors

Jennifer Cable¹, Mark R Denison², Margaret Kielian³, William T Jackson⁴, Ralf Bartenschlager⁵, Tero Ahola⁶, Suchetana Mukhopadhyay⁷, Daved H Fremont⁸, Richard J Kuhn⁹, Ashleigh Shannon¹⁰, Meredith N Frazier¹¹, Kwok-Yung Yuen^{12

13}, Carolyn B Coyne¹⁴, Katja C Wolthers¹⁵, Guo-Li Ming¹⁶, Camy S Guenther¹⁷, Jasmine Moshiri¹⁸, Sonja M Best¹⁹, John W Schoggins²⁰, Kellie Ann Jurado²¹, Gregory D Ebel²², Alexandra Schäfer²³, Lisa F P Ng^{24

25}, Marjolein Kikkert²⁶, Alessandro Sette^{27

28}, Eva Harris²⁹, Peter A C Wing³⁰, Julie Eggenberger³¹, Siddharth R Krishnamurthy³², Marcus G Mah³³, Rita M Meganck²³, Donghoon Chung³⁴, Sebastian Maurer-Stroh^{35

36}, Raul Andino³⁷, Bette Korber³⁸, Stanley Perlman³⁹, Pei-Yong Shi⁴⁰, Montserrat Bárcena⁴¹, Sophie-Marie Aicher⁴², Michelle N Vu⁴³, Devin J Kenney⁴⁴, Brett D Lindenbach⁴⁵, Yukiko Nishida^{46

47}, Laurent Rénia²⁴, Evan P Williams⁴⁸

Affiliations

¹ PhD Science Writer, New York, New York, USA.
² Department of Pediatrics and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center; and Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, Tennessee, USA.
³ Department of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA.
⁴ Department of Microbiology and Immunology and Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁵ Department of Infectious Diseases, Molecular Virology, Heidelberg University and German Cancer Research Center (DKFZ), Research Division Virus-associated Carcinogenesis, Heidelberg, Germany.
⁶ Department of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Helsinki, Finland.
⁷ Department of Biology, Indiana University, Bloomington, Indiana, USA.
⁸ Department of Pathology & Immunology; Department of Molecular Microbiology; and Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
⁹ Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
¹⁰ Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix Marseille Université, Marseille, France.
¹¹ Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
¹² Department of Microbiology, Li Ka Shing Faculty of Medicine and State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People's Republic of China.
¹³ Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong, People's Republic of China.
¹⁴ Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.
¹⁵ Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam and Amsterdam Institute for Infection and Immunity, OrganoVIR Labs, Amsterdam, The Netherlands.
¹⁶ Department of Neuroscience and Mahoney Institute for Neurosciences, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
¹⁷ Colorado State University, Fort Collins, Colorado, USA.
¹⁸ Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
¹⁹ Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
²⁰ Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
²¹ Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
²² Center for Vector-borne Infectious Diseases, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
²³ Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
²⁴ ASTAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science Technology and Research (A*STAR), Singapore City, Singapore.
²⁵ National Institute of Health Research, Health Protection Research Unit in Emerging and Zoonotic Infections; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
²⁶ Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
²⁷ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
²⁸ Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
²⁹ Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, USA.
³⁰ Nuffield Department of Medicine and Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
³¹ Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA.
³² Metaorganism Immunity Section, Laboratory of Immune System Biology and NIAID Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
³³ Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore City, Singapore.
³⁴ Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas, USA.
³⁵ Yong Loo Lin School of Medicine and Department of Biological Sciences, National University of Singapore, Singapore City, Singapore.
³⁶ Bioinformatics Institute, Agency for Science, Technology and Research, Singapore City, Singapore.
³⁷ Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.
³⁸ Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
³⁹ Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
⁴⁰ Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
⁴¹ Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
⁴² Institut Pasteurgrid, Université de Paris Cité, Virus Sensing and Signaling Unit, Paris, France.
⁴³ Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
⁴⁴ Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, Massachusetts, USA.
⁴⁵ Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
⁴⁶ Chugai Pharmaceutical, Co., Tokyo, Japan.
⁴⁷ Lee Kong Chian School of Medicine and School of Biological Sciences, Nanyang Technological University, Singapore City, Singapore.
⁴⁸ Department of Microbiology, Immunology, and Biochemistry, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Abstract

Positive-strand RNA viruses have been the cause of several recent outbreaks and epidemics, including the Zika virus epidemic in 2015, the SARS outbreak in 2003, and the ongoing SARS-CoV-2 pandemic. On June 18-22, 2022, researchers focusing on positive-strand RNA viruses met for the Keystone Symposium "Positive-Strand RNA Viruses" to share the latest research in molecular and cell biology, virology, immunology, vaccinology, and antiviral drug development. This report presents concise summaries of the scientific discussions at the symposium.

Keywords: RNA virus; SARS-CoV-2; alphavirus; coronavirus; enterovirus; flavivirus.

Publication types

Research Support, U.S. Gov't, P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural

MeSH terms

Antiviral Agents / therapeutic use
COVID-19*
Humans
Pandemics
Positive-Strand RNA Viruses
SARS-CoV-2
Zika Virus Infection* / drug therapy
Zika Virus Infection* / epidemiology
Zika Virus Infection* / prevention & control
Zika Virus*

Substances

Antiviral Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding