Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report

Anat R Tambur; Oriol Bestard; Patricia Campbell; Anita S Chong; Martha Crespo Barrio; Mandy L Ford; Howard M Gebel; Sebastiaan Heidt; Michelle Hickey; Annette Jackson; Vasilis Kosmoliaptsis; Carmen Lefaucheur; Kevin Louis; Roslyn B Mannon; Michael Mengel; Anna Morris; David F Pinelli; Elaine F Reed; Carrie Schinstock; Jean-Luc Taupin; Nicole Valenzuela; Chris Wiebe; Peter Nickerson

doi:10.1016/j.ajt.2022.11.009

Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report

Am J Transplant. 2023 Jan;23(1):133-149. doi: 10.1016/j.ajt.2022.11.009. Epub 2023 Jan 11.

Authors

Anat R Tambur¹, Oriol Bestard², Patricia Campbell³, Anita S Chong⁴, Martha Crespo Barrio⁵, Mandy L Ford⁶, Howard M Gebel⁷, Sebastiaan Heidt⁸, Michelle Hickey⁹, Annette Jackson¹⁰, Vasilis Kosmoliaptsis¹¹, Carmen Lefaucheur¹², Kevin Louis¹², Roslyn B Mannon¹³, Michael Mengel³, Anna Morris⁷, David F Pinelli¹⁴, Elaine F Reed⁹, Carrie Schinstock¹⁵, Jean-Luc Taupin¹⁶, Nicole Valenzuela⁹, Chris Wiebe¹⁷, Peter Nickerson¹⁷

Affiliations

¹ Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, Illinois, USA. Electronic address: a-tambur@northwestern.edu.
² Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Barcelona, Spain.
³ Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, Canada.
⁴ Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, Illinois, USA.
⁵ Department of Nephrology, Hospital del Mar & Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
⁶ Department of Surgery and Emory Transplant Center, Emory University, Atlanta, Georgia, USA.
⁷ Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
⁸ Department of Immunology, Leiden University Medical Center, Netherlands.
⁹ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
¹⁰ Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA.
¹¹ Department of Surgery, University of Cambridge, Cambridge, UK.
¹² Paris Translational Research Center for Organ Transplantation, Institut national de la santé et de la recherche médicale UMR-S970, Université de Paris, Paris, France.
¹³ Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
¹⁴ Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, Illinois, USA.
¹⁵ Department of Medicine, Mayo Clinical, Rochester, Minnesota, USA.
¹⁶ Department of Immunology, Saint Louis Hospital and University Paris-Cité, Paris, France.
¹⁷ Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

PMID: 36695615
DOI: 10.1016/j.ajt.2022.11.009

Abstract

The Sensitization in Transplantation: Assessment of Risk workgroup is a collaborative effort of the American Society of Transplantation and the American Society of Histocompatibility and Immunogenetics that aims at providing recommendations for clinical testing, highlights gaps in current knowledge, and proposes areas for further research to enhance histocompatibility testing in support of solid organ transplantation. This report provides updates on topics discussed by the previous Sensitization in Transplantation: Assessment of Risk working groups and introduces 2 areas of exploration: non-human leukocyte antigen antibodies and utilization of human leukocyte antigen antibody testing measurement to evaluate the efficacy of antibody-removal therapies.

Keywords: B-cell biology; T-cell biology; alloantibody; clinical research/practice; desensitization; guidelines; histocompatibility; immunobiology; solid organ transplantation; translational research/science.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Graft Rejection / etiology
Group Processes
Histocompatibility
Histocompatibility Testing
Isoantibodies
Organ Transplantation* / adverse effects
Risk Factors

Substances

Isoantibodies