Frustoconical porous microneedle for electroosmotic transdermal drug delivery

Daigo Terutsuki; Reiji Segawa; Shinya Kusama; Hiroya Abe; Matsuhiko Nishizawa

doi:10.1016/j.jconrel.2023.01.055

Frustoconical porous microneedle for electroosmotic transdermal drug delivery

J Control Release. 2023 Feb:354:694-700. doi: 10.1016/j.jconrel.2023.01.055. Epub 2023 Jan 25.

Authors

Daigo Terutsuki¹, Reiji Segawa², Shinya Kusama¹, Hiroya Abe¹, Matsuhiko Nishizawa³

Affiliations

¹ Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan.
² Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-04 Aramaki Aoba, Aoba-ku, Sendai 980-8579, Japan.
³ Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan; Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-04 Aramaki Aoba, Aoba-ku, Sendai 980-8579, Japan; Division for the Establishment of Frontier Sciences of the Organization for Advanced Studies, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan. Electronic address: nishizawa@tohoku.ac.jp.

PMID: 36693528
DOI: 10.1016/j.jconrel.2023.01.055

Abstract

A truncated cone-shaped porous microneedle (PMN) made of poly-glycidyl methacrylate was studied as a minimally invasive tool for transdermal drug delivery. The transdermal electrical resistance of a pig skin was evaluated during the indentation of the PMNs, revealing that the frustoconical PMN (300 μm height) significantly reduced the resistance of the skin by expanding the stratum corneum without penetrating into the skin. A thin film of poly (2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) was grafted onto the inner wall of the microchannels of the frustoconical PMN to generate electroosmotic flow (EOF) upon current application in the direction of injection of the drug into the skin. Owing to the synergy of the expansion of the stratum corneum and the EOF-promotion, the PAMPS-modified frustoconical PMN effectively enhances the penetration of larger (over 500 Da) molecules, such as dextran (∼10 kDa).

Keywords: Electroosmosis; Frustoconical protrusion; Porous microneedle; Transdermal delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Cutaneous
Animals
Drug Delivery Systems
Electroosmosis*
Microinjections
Needles
Pathogen-Associated Molecular Pattern Molecules*
Porosity
Skin
Swine

Substances

Pathogen-Associated Molecular Pattern Molecules