Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics

Zlata Boiarska; Helena Pérez-Peña; Anne-Catherine Abel; Paola Marzullo; Beatriz Álvarez-Bernad; Francesca Bonato; Benedetta Santini; Dragos Horvath; Daniel Lucena-Agell; Francesca Vasile; Maurizio Sironi; J Fernando Díaz; Andrea E Prota; Stefano Pieraccini; Daniele Passarella

doi:10.1002/chem.202300069

Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics

Chemistry. 2023 Jan 24;29(5):e202300069. doi: 10.1002/chem.202300069.

Authors

Affiliations

¹ Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy.
² Laboratory of Biomolecular Research, Paul Scherrer Institute, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland.
³ Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas Ramiro de Maeztu 9, 28040, Madrid, Spain.
⁴ Laboratory of Chemoinformatics, Faculty of Chemistry, University of Strasbourg, rue B. Pascal, 67081, Strasbourg, France.

PMID: 36692211
DOI: 10.1002/chem.202300069

Abstract

Invited for the cover of this issue are the groups of Professors Passarella and Pieraccini at the University of Milan, in collaboration with some of the members of TubInTrain consortium. The image depicts work with the elements of nature, in particular the destabilising effect of maytansinol (the constellation) on microtubules (the trees). Read the full text of the article at 10.1002/chem.202203431.

MeSH terms

Maytansine*
Microtubules
Research
Social Group

Substances

maytansinol
Maytansine