Palladium(0)-Catalyzed Anti-Selective Addition-Cyclizations of Alkynyl Electrophiles

Hirokazu Tsukamoto; Kazuya Ito; Tatsuhiko Ueno; Mitsugu Shiraishi; Yoshinori Kondo; Takayuki Doi

doi:10.1002/chem.202300086

Palladium(0)-Catalyzed Anti-Selective Addition-Cyclizations of Alkynyl Electrophiles

Chemistry. 2023 Jan 27;29(6):e202300086. doi: 10.1002/chem.202300086. Epub 2023 Jan 23.

Authors

Hirokazu Tsukamoto^{1

2}, Kazuya Ito², Tatsuhiko Ueno², Mitsugu Shiraishi², Yoshinori Kondo², Takayuki Doi²

Affiliations

¹ Department of Pharmaceutical Sciences, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, 245-0066, Japan.
² Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.

PMID: 36690588
DOI: 10.1002/chem.202300086

Abstract

Invited for the cover of this issue is the group of Hirokazu Tsukamoto at Tohoku University (current affiliation: Yokohama University of Pharmacy). The image depicts anti-selective arylative cyclization reactions of alkynyl aldehydes with arylboronic acids under palladium catalysis in methanol to afford endo- and exo-cyclic products. Read the full text of the article at 10.1002/chem.202203068.