Dietary intake of animal-based products and likelihood of follicular lymphoma and survival: A population-based family case-control study

Michael K Odutola; Marina T van Leeuwen; Julie K Bassett; Fiona Bruinsma; Jennifer Turner; John F Seymour; Henry Miles Prince; Samuel T Milliken; Mark Hertzberg; Fernando Roncolato; Stephen S Opat; Robert Lindeman; Campbell Tiley; Judith Trotman; Emma Verner; Michael Harvey; Craig R Underhill; Geza Benke; Graham G Giles; Claire M Vajdic

doi:10.3389/fnut.2022.1048301

Dietary intake of animal-based products and likelihood of follicular lymphoma and survival: A population-based family case-control study

Front Nutr. 2023 Jan 4:9:1048301. doi: 10.3389/fnut.2022.1048301. eCollection 2022.

Authors

Michael K Odutola¹, Marina T van Leeuwen¹, Julie K Bassett², Fiona Bruinsma², Jennifer Turner^{3

4}, John F Seymour⁵, Henry Miles Prince⁶, Samuel T Milliken⁷, Mark Hertzberg⁸, Fernando Roncolato^{9

10}, Stephen S Opat¹¹, Robert Lindeman¹², Campbell Tiley¹³, Judith Trotman¹⁴, Emma Verner¹⁴, Michael Harvey¹⁵, Craig R Underhill¹⁶, Geza Benke¹⁷, Graham G Giles^{2

18}, Claire M Vajdic^{1

19}

Affiliations

¹ Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, Australia.
² Cancer Epidemiology Division, Cancer Council Victoria, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.
³ Douglass Hanly Moir Pathology, Macquarie Park, NSW, Australia.
⁴ Department of Clinical Medicine, Faculty of Medicine, Health and Human Science, Macquarie University, Sydney, NSW, Australia.
⁵ Royal Melbourne Hospital, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia.
⁶ Epworth Healthcare and Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.
⁷ St. Vincent's Hospital, University of New South Wales, Sydney, NSW, Australia.
⁸ Department of Haematology, Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia.
⁹ St. George Hospital, Kogarah, NSW, Australia.
¹⁰ St. George Clinical School, University of New South Wales, Kogarah, NSW, Australia.
¹¹ Clinical Haematology, Monash Health and Monash University, Clayton, VIC, Australia.
¹² New South Wales Health Pathology, University of New South Wales, Sydney, NSW, Australia.
¹³ Gosford Hospital, The University of Newcastle, Callaghan, NSW, Australia.
¹⁴ Concord Repatriation General Hospital, University of Sydney, Concord, NSW, Australia.
¹⁵ Liverpool Hospital, Western Sydney University, Liverpool, NSW, Australia.
¹⁶ Border Medical Oncology Research Unit, Rural Medical School, Albury, NSW, Australia.
¹⁷ School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
¹⁸ Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia.
¹⁹ The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

Abstract

Background: The association between dietary intake of foods of animal origin and follicular lymphoma (FL) risk and survival is uncertain. In this study, we examined the relationship between dietary intake of dairy foods and fats, meat, fish and seafoods, and the likelihood of FL and survival.

Methods: We conducted a population-based family case-control study in Australia between 2011 and 2016 and included 710 cases, 303 siblings and 186 spouse/partner controls. We assessed dietary intake of animal products prior to diagnosis (the year before last) using a structured food frequency questionnaire and followed-up cases over a median of 6.9 years using record linkage to national death data. We examined associations with the likelihood of FL using logistic regression and used Cox regression to assess association with all-cause and FL-specific mortality among cases.

Results: We observed an increased likelihood of FL with increasing daily quantity of oily fish consumption in the year before last (highest category OR = 1.96, CI = 1.02-3.77; p-trend 0.06) among cases and sibling controls, but no associations with spouse/partner controls. We found no association between the likelihood of FL and the consumption of other types of fish or seafood, meats or dairy foods and fats. In FL cases, we found no association between meat or oily fish intake and all-cause or FL-specific mortality.

Conclusion: Our study showed suggestive evidence of a positive association between oily fish intake and the likelihood of FL, but findings varied by control type. Further investigation of the potential role of environmental contaminants in oily fish on FL etiology is warranted.

Keywords: animal product; fish; follicular lymphoma; risk; survival.