The oral manifestations and related mechanisms of COVID-19 caused by SARS-CoV-2 infection

Weiming Lin; Feng Gao; Xia Wang; Nianhong Qin; Xianxiong Chen; Kin Yip Tam; Chengfei Zhang; Mingxia Zhang; Ou Sha

doi:10.3389/fncel.2022.1006977

The oral manifestations and related mechanisms of COVID-19 caused by SARS-CoV-2 infection

Front Cell Neurosci. 2023 Jan 4:16:1006977. doi: 10.3389/fncel.2022.1006977. eCollection 2022.

Authors

Weiming Lin¹, Feng Gao², Xia Wang¹, Nianhong Qin¹, Xianxiong Chen², Kin Yip Tam³, Chengfei Zhang^{1

4}, Mingxia Zhang⁵, Ou Sha²

Affiliations

¹ Shenzhen University Medical School, Shenzhen, China.
² School of Dentistry, Shenzhen University Medical School, Shenzhen, China.
³ Faculty of Health Sciences, University of Macau, Macau, Macau SAR, China.
⁴ School of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
⁵ The Third People's Hospital of Shenzhen, Shenzhen, China.

Abstract

Coronavirus disease 2019 (COVID-19) was reported to be associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, and patients present mostly with respiratory symptoms. There have been an increasing number of reports on oral manifestations, and some of these signs are informative in terms of identifying SARS-CoV-2 infection. The goal of present study was to review and synthesize the clinical characteristics and underlying mechanisms of COVID-19 oral manifestations, as well as to evaluate the factors influencing SARS-CoV-2 infectivity, in order to conduct further in-depth investigations and help clinicians diagnose COVID-19 patients exhibiting oral symptoms.

Keywords: ACE2 receptor; COVID-19; SARS-CoV-2; TMPRSS2; influential factors; oral manifestations.

Publication types

Review