Prevalence and genotype distribution of human papillomavirus infection among HIV-infected men who have sex with men living in Lower Silesia, Poland

Martyna Biała; Małgorzata Zalewska; Bartosz Szetela; Jacek Gąsiorowski; Jarosław Leszczyszyn; Małgorzata Inglot

doi:10.5114/ada.2022.122607

Prevalence and genotype distribution of human papillomavirus infection among HIV-infected men who have sex with men living in Lower Silesia, Poland

Postepy Dermatol Alergol. 2022 Dec;39(6):1128-1133. doi: 10.5114/ada.2022.122607. Epub 2022 Dec 22.

Authors

Martyna Biała¹, Małgorzata Zalewska¹, Bartosz Szetela^{1

2}, Jacek Gąsiorowski², Jarosław Leszczyszyn³, Małgorzata Inglot^{1

2}

Affiliations

¹ Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiencies, Wroclaw Medical University, Wroclaw, Poland.
² Department of HIV/AIDS, HIV Outpatient Clinic, Wroclaw, Poland.
³ Department of Gastroenterology and Proctology, Melita Medical, Wroclaw, Poland.

Abstract

Introduction: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and is associated with the risk of anogenital and oropharyngeal cancers. Men who have sex with men (MSM) are at a high risk of HPV infection. However, little up-to-date data are available regarding the prevalence of HIV and HPV co-infection in MSM in Poland.

Aim: To evaluate the prevalence, genotype distribution and risk factors for HPV infection among HIV-positive MSM living in Lower Silesia.

Material and methods: A total of 54 HIV-positive and 28 HIV-negative MSM participated in the study. The polymerase chain reaction was performed to detect HPV from oral and anal swabs. A self-applied written questionnaire was conducted to collect sociodemographic and behavioural data.

Results: The prevalence rates of oral and anal HPV infection were higher in HIV-infected MSM than in HIV-negative MSM. Statistical analysis showed that the prevalence of high oncogenic genotypes, HPV 16 and HPV 18, at the anal site was significantly higher in patients with lower CD4 cell counts, in addition, HPV 18 infection was significantly more frequent in patients with higher levels of HIV RNA. Moreover, HPV 33 and HPV 52 at the anal site were significantly more common in patients with lower nadir CD4.

Conclusions: This is the first report of HPV infection among Polish HIV-infected MSM. Our results show that HIV-related immunodeficiency is associated with a higher prevalence of high-risk HPV infections, therefore early detection of HIV infection and initiation of antiretroviral therapy might reduce the risk of HPV-related diseases.

Keywords: HIV; human papillomavirus; men who have sex with men (MSM); sexually transmitted infection; sexually transmitted infections.