High expression of KNL1 in prostate adenocarcinoma is associated with poor prognosis and immune infiltration

Yetao Zhang; Qianying Ji; Jun Wang; Yuxiang Dong; Mingyang Pang; Shengqiang Fu; Yong Wei; Qingyi Zhu

doi:10.3389/fgene.2022.1100787

High expression of KNL1 in prostate adenocarcinoma is associated with poor prognosis and immune infiltration

Front Genet. 2023 Jan 6:13:1100787. doi: 10.3389/fgene.2022.1100787. eCollection 2022.

Authors

Yetao Zhang¹, Qianying Ji², Jun Wang², Yuxiang Dong¹, Mingyang Pang¹, Shengqiang Fu¹, Yong Wei¹, Qingyi Zhu^{1

2}

Affiliations

¹ Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
² Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Abstract

Prostate adenocarcinoma (PRAD) is a common malignancy with increasing morbidity and mortality. Kinetochore scaffold 1 (KNL1) has been reported to be involved in tumor progression and prognosis in other tumors, but its role in PRAD has not been reported in detail. KNL1 expression analysis, clinicopathological parameters analysis, prognostic correlation analysis, molecular interaction network and functional abdominal muscle analysis and immune infiltration analysis by using multiple online databases and downloaded expression profile. The results suggest that KNL1 is highly expressed in PRAD, which is associated with worse prognosis in PRAD patients. KnL1-related genes are highly enriched in mitotic function, which is considered to be highly related to the development of cancer. Finally, KNL1 expression is associated with a variety of tumor infiltrating immune cells, especially Treg and Th2 cells. In conclusion, our findings provide preliminary evidence that KNL1 may be an independent prognostic predictor of PRAD and is associated with immune infiltration.

Keywords: Knl1; bioinformatics analysis; immune infiltration; prognosis; prostate adenocarcinoma.