Association between global biomarker of oxidative stress and quantitative ultrasound parameters in middle-aged and elderly adults: A cross-sectional study

Xue Shen; Yawen Liu; Qianqian Zhao; Haitao Cheng; Binbin Li; Ann M Vuong; Yiliang Fan; Mengmeng Zhang; Shuman Yang

doi:10.3389/fpubh.2022.1032550

Association between global biomarker of oxidative stress and quantitative ultrasound parameters in middle-aged and elderly adults: A cross-sectional study

Front Public Health. 2023 Jan 6:10:1032550. doi: 10.3389/fpubh.2022.1032550. eCollection 2022.

Authors

Xue Shen¹, Yawen Liu¹, Qianqian Zhao¹, Haitao Cheng², Binbin Li¹, Ann M Vuong³, Yiliang Fan¹, Mengmeng Zhang², Shuman Yang¹

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
² FAW General Hospital of Jilin Province, Changchun, China.
³ Department of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas, NV, United States.

Abstract

Introduction: With the population aging, osteoporosis has become a major public health concern. Elevated oxidative stress is a vital detrimental factor for bone health. Compared to common oxidative stress-related biomarkers, Fluorescent Oxidation Products (FlOPs) reflect the global levels of oxidation from proteins, lipids, and DNA. Nevertheless, whether plasma FlOP levels are related to bone health measured by Quantitative ultrasound (QUS) is unclear. Thus, the present study examined the association between FlOPs and QUS parameters in middle-aged and elderly adults.

Methods: This community-based cross-sectional study was conducted in Changchun, northeast China. Plasma FlOPs were determined by a fluorescent microplate reader at a wavelength of 320/420 nm (excitation/emission). QUS parameters [speed of sound (SOS) and broadband ultrasound attenuation (BUA)] of the calcaneus were assessed by an ultrasound bone densitometer. We used multivariable linear regression to examine the association between FlOPs and QUS parameters.

Results: A total of 491 subjects were included in this study. Their average age was 65.2 years (standard deviation [SD]: 9.7 years). FlOPs were inversely associated with SOS (β for an increase of logarithmic interquartile range = -10.64; P = 0.018). Higher FlOP levels were marginally associated with lower SOS in females (β for an increase of logarithmic interquartile range = -9.68, P = 0.066), but not in males (β for an increase of logarithmic interquartile range = -11.84, P = 0.131). No significant relationship between FlOPs and BUA was observed.

Conclusions: Plasma FlOP levels were inversely associated with SOS, but not with BUA in middle-aged and elderly adults.

Keywords: broadband ultrasound attenuation; fluorescent oxidation products; middle-aged and elderly adults; oxidative stress; quantitative ultrasound parameters; speed of sound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aging*
Biomarkers
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Osteoporosis* / diagnostic imaging
Oxidative Stress
Ultrasonography

Substances

Biomarkers

Grants and funding

The present study was supported by the National Key R&D Program of China (Grant #2018YFC1311600). This work was also partly supported by research grants from the Jilin Scientific and Technological Development Program (Grant Number: 20210101431JC), and the Changchun Science and Technology Planning Project (Grant Numbers: 21ZGM28 and 21ZGM27).