Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer: A critical review

Yi-Lin Zhong; Peng-Qian Wang; Dan-Li Hao; Feng Sui; Feng-Bin Zhang; Bing Li

doi:10.4251/wjgo.v15.i1.36

Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer: A critical review

World J Gastrointest Oncol. 2023 Jan 15;15(1):36-54. doi: 10.4251/wjgo.v15.i1.36.

Authors

Yi-Lin Zhong¹, Peng-Qian Wang¹, Dan-Li Hao¹, Feng Sui¹, Feng-Bin Zhang², Bing Li³

Affiliations

¹ Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
² Department of Gastroenterology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China.
³ Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. libingtcm@163.com.

Abstract

Gastric cancer (GC) is a common gastrointestinal tumor. Gastric precancerous lesions (GPL) are the last pathological stage before normal gastric mucosa transforms into GC. However, preventing the transformation from GPL to GC remains a challenge. Traditional Chinese medicine (TCM) has been used to treat gastric disease for millennia. A series of TCM formulas and active compounds have shown therapeutic effects in both GC and GPL. This article reviews recent progress on the herbal drugs and pharmacological mechanisms of TCM in preventing the transformation from GPL to GC, especially focusing on anti-inflammatory, anti-angiogenesis, proliferation, and apoptosis. This review may provide a meaningful reference for the prevention of the transformation from GPL to GC using TCM.

Keywords: Formulas; Gastric cancer; Gastric precancerous lesions; Inflammation-cancer transformation; Pharmacological mechanism; Traditional Chinese medicine.

Publication types

Review