Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice

Fei Zeng; Karsten Parker; Yanqiang Zhan; Matthew Miller; Meng-Yang Zhu

doi:10.1177/17590914231152099

Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice

ASN Neuro. 2023 Jan-Dec:15:17590914231152099. doi: 10.1177/17590914231152099.

Authors

Fei Zeng^{1

2}, Karsten Parker², Yanqiang Zhan^{1

2}, Matthew Miller², Meng-Yang Zhu²

Affiliations

¹ Department of Neurology, Renmin Hospital of the Wuhan University, Wuhan, China.
² Departments of Biomedical Sciences, Quillen College of Medicine, 4154East Tennessee State University, Johnson City, TN, USA.

Abstract

The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.

Keywords: ATM/ATRdopamine; DNA damage; locus coeruleus; oxidation stress; substantia nigra; γH2AX.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Biomarkers
Brain / metabolism
DNA Damage*
Disease Models, Animal
Mice
Oxidative Stress*
Parkinson Disease* / genetics
Parkinson Disease* / metabolism

Substances

Biomarkers
Slc18a2 protein, mouse

Grants and funding

R15 AG055107/AG/NIA NIH HHS/United States