Exosomes as perioperative therapeutics to limit organ injury

Andrew Owen; Creed M Stary; Eric R Gross

doi:10.1016/j.bja.2022.12.014

Exosomes as perioperative therapeutics to limit organ injury

Br J Anaesth. 2023 Mar;130(3):248-250. doi: 10.1016/j.bja.2022.12.014. Epub 2023 Jan 20.

Authors

Andrew Owen¹, Creed M Stary², Eric R Gross²

Affiliations

¹ Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK. Electronic address: a.owen.2@bham.ac.uk.
² Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA.

PMID: 36682935
DOI: 10.1016/j.bja.2022.12.014

Abstract

Perioperative organ injury is a frequent and major complication for the ∼240 million people undergoing surgery worldwide annually. Ischaemic preconditioning is a powerful technique that reduces organ injury in experimental models of heart, lung, gut, brain, and kidney ischaemia-reperfusion injury. However, ischaemic preconditioning has been a challenge to translate into clinical practice. We describe how utilising isolated pre-conditioned exosomes (secreted vesicles containing many cell-survival mediators), some of the translational hurdles of ischaemic preconditioning can be overcome. Delivery of exosomes in the perioperative period could become a promising new therapeutic strategy to prevent perioperative organ injury.

Keywords: exosome; extracellular vesicle; heart; infarction; ischaemia; reperfusion.

Publication types

Editorial
Comment

MeSH terms

Exosomes*
Humans
Ischemic Preconditioning* / methods
Ischemic Preconditioning, Myocardial* / methods
Kidney
Reperfusion Injury* / prevention & control

Abstract

Publication types

MeSH terms

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