Good and evil, more reasons to study UPR

Reiko Inagi; Sho Hasegawa

doi:10.1016/j.kint.2022.09.015

Good and evil, more reasons to study UPR

Kidney Int. 2023 Feb;103(2):254-256. doi: 10.1016/j.kint.2022.09.015.

Authors

Reiko Inagi¹, Sho Hasegawa²

Affiliations

¹ Division of CKD Pathophysiology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan. Electronic address: inagi-r@m.u-tokyo.ac.jp.
² Division of CKD Pathophysiology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.

PMID: 36681453
DOI: 10.1016/j.kint.2022.09.015

Abstract

The unfolded protein response (UPR) pathway, launched by endoplasmic reticulum, maintains endoplasmic reticulum homeostasis. Dysregulated UPR pathway links disease phenotypes, such as proteinuria, inflammation, and fibrosis, in kidney disease. Although accumulating evidence indicates the beneficial impact of the UPR pathway as a therapeutic target for various diseases, including kidney disease, the control of adaptive UPR status is still difficult for disease treatment. This article may give us a new insight into the strategy for sustaining the kidney protective UPR pathway.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Endoplasmic Reticulum Stress
Homeostasis
Humans
Kidney
Kidney Diseases* / therapy
Unfolded Protein Response*