Pharmacokinetic and Pharmacodynamic Effects of Polyclonal Antibodies against SARS-CoV2 in Mice

Aruni Jha; Melanie Doyle-Eisele; David Revelli; Trevor Carnelley; Douglas Barker; Shantha Kodihalli

doi:10.3390/v15010123

Pharmacokinetic and Pharmacodynamic Effects of Polyclonal Antibodies against SARS-CoV2 in Mice

Viruses. 2022 Dec 30;15(1):123. doi: 10.3390/v15010123.

Authors

Aruni Jha¹, Melanie Doyle-Eisele², David Revelli², Trevor Carnelley¹, Douglas Barker¹, Shantha Kodihalli¹

Affiliations

¹ Emergent BioSolutions Canada Inc., Winnipeg, MB R3T 5Y3, Canada.
² Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA.

Abstract

Despite ongoing vaccination efforts to prevent SARS-CoV-2 infections, treatment tools are still necessary to address the ongoing COVID-19 pandemic. We report here that COVID-HIGIV, a human immunoglobulin product for treatment of COVID-19, provided a significant survival benefit in SARS-CoV-2 infected transgenic mice compared to controls. COVID-HIGIV also has similar pharmacokinetic profiles in healthy and SARS-CoV-2 infected mice over time after intravenous administration, with identical or comparable Tmax, Cmax, AUC_0-∞ and Cl. AUC_0-last increased and mean residence time, T_1/2, and Vd reduced in infected animals compared to healthy animals. These data suggest that COVID-HIGIV may be an effective treatment for SARS-CoV-2 infection when given early after exposure.

Keywords: COVID-19; mouse model; pharmacodynamics; pharmacokinetics.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Antibodies
COVID-19*
Humans
Mice
Pandemics / prevention & control
RNA, Viral
SARS-CoV-2

Substances

RNA, Viral
Antibodies

Grants and funding

This research was funded by the U.S. Department of Defense’s Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), in collaboration with the Defense Health Agency, under Other Transaction number W911QY-20-9-0013, to Emergent BioSolutions Canada Inc for the development of COVID-HIGIV, a countermeasure to SARS-CoV-2. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government.