The Role of NLRP3 Inflammasome in IgA Nephropathy

Xiaofang Wu; Lei Zhao; Kailong Li; Jurong Yang

doi:10.3390/medicina59010082

The Role of NLRP3 Inflammasome in IgA Nephropathy

Medicina (Kaunas). 2022 Dec 30;59(1):82. doi: 10.3390/medicina59010082.

Authors

Xiaofang Wu¹, Lei Zhao¹, Kailong Li¹, Jurong Yang¹

Affiliation

¹ Department of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 400120, China.

Abstract

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide today. The NLRP3 inflammasome is a polyprotein complex and an important participant in inflammation. Accumulating studies have shown that the NLRP3 inflammasome participates in a variety of kidney diseases, including IgAN. This review focuses on the role of the NLRP3 inflammasome in IgAN and summarizes multiple involved pathways, which may provide novel treatments for IgAN treatment.

Keywords: IgA nephropathy; NF-κB; NLRP3 inflammasome; ROS; autophagy; exosomes.

Publication types

Review

MeSH terms

Glomerulonephritis, IGA*
Humans
Inflammasomes / metabolism
Inflammation / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein

Grants and funding

This research received no external funding.