Genetic Predisposition to Neurological Complications in Patients with COVID-19

Nikhil Shri Sahajpal; Alex R Hastie; Maximilian Schieck; Ashis K Mondal; Marc Felde; Caspar I van der Made; Janet S Chou; Adrienne G Randolph; Thomas Illig; Michael C Zody; Catherine A Brownstein; Alan H Beggs; Alexander Hoischen; Alka Chaubey; Ravindra Kolhe; COVID19hostgenomesv Consortium

doi:10.3390/biom13010133

Genetic Predisposition to Neurological Complications in Patients with COVID-19

Biomolecules. 2023 Jan 9;13(1):133. doi: 10.3390/biom13010133.

Authors

Nikhil Shri Sahajpal^{1

2}, Alex R Hastie³, Maximilian Schieck^{4

5}, Ashis K Mondal¹, Marc Felde⁶, Caspar I van der Made^{7

8

9}, Janet S Chou¹⁰, Adrienne G Randolph^{11

12}, Thomas Illig^{4

5}, Michael C Zody¹³, Catherine A Brownstein¹⁴, Alan H Beggs¹⁴, Alexander Hoischen^{7

8

9}, Alka Chaubey³, Ravindra Kolhe¹; COVID19hostgenomesv Consortium

Affiliations

¹ Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
² Greenwood Genetic Center, Greenwood, SC 29646, USA.
³ Bionano Genomics, Inc., San Diego, CA 92121, USA.
⁴ Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany.
⁵ RESIST-Cluster of Excellence 2155, Hannover Medical School, 30625 Hannover, Germany.
⁶ Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
⁷ Department of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands.
⁸ Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
⁹ Radboud Expertise Center for Immunodeficiency and Autoinflammation, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
¹⁰ Division of Immunology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
¹¹ Department of Anesthesiology, Critical Care, and Pain Medicine, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
¹² Departments of Anesthesia and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
¹³ New York Genome Center, New York, NY 10013, USA.
¹⁴ Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.

Keywords: COVID-19; genetic predisposition; neurological complications; optical genome mapping; rare SVs.

MeSH terms

COVID-19* / complications
COVID-19* / genetics
Genetic Predisposition to Disease
Genotype
Humans
Nervous System Diseases* / genetics

Grants and funding

P50 HD105351/HD/NICHD NIH HHS/United States