MicroRNAs induced by Listeria monocytogenes and their role in cells

Javad Allahverdy; Niloufar Rashidi

doi:10.1016/j.micpath.2023.105997

MicroRNAs induced by Listeria monocytogenes and their role in cells

Microb Pathog. 2023 Feb:175:105997. doi: 10.1016/j.micpath.2023.105997. Epub 2023 Jan 18.

Authors

Javad Allahverdy¹, Niloufar Rashidi²

Affiliations

¹ Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: allahverdy.ja@iums.ac.ir.
² Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: ni.rashidi@gmail.com.

PMID: 36669673
DOI: 10.1016/j.micpath.2023.105997

Abstract

Listeria monocytogenes (Lm) causes abortions at high rates and threatens newborns' lives. Also, the elderly and immunocompromised individuals are particularly vulnerable neurologically. The bacterium exerts its pathogenesis intracellularly by manipulating cell organs. It manipulates nucleus elements, microRNAs (miRNAs), in order to increase survival and evade immunity. miRNAs are small non-coding RNAs that degrade gene expression post-transcriptionally. Any alteration to the expression of miRNAs affects various cascades in cells, especially immunity-related responses. Thus, utilizing miRNAs as a novel therapeutic agent not only restricts infection but enhances immunity reactions. This review provides an overview of miRNAs in listeriosis, their role in cells, and their prospects as therapy.

Keywords: Abortion; Listeria monocytogenes; Listeriosis; microRNA; microRNA therapy.

Publication types

Review

MeSH terms

Aged
Female
Humans
Infant, Newborn
Listeria monocytogenes* / metabolism
Listeriosis* / microbiology
MicroRNAs* / genetics
MicroRNAs* / metabolism
Pregnancy

Substances

MicroRNAs