Effect of Percutaneous Endoscopic Gastrostomy on Quality of Life after Chemoradiation for Locally Advanced Nasopharyngeal Carcinoma: A Cross-Sectional Study

Yun Xu; Hewei Peng; Qiaojuan Guo; Lanyan Guo; Xiane Peng; Shaojun Lin

doi:10.3390/curroncol30010076

Effect of Percutaneous Endoscopic Gastrostomy on Quality of Life after Chemoradiation for Locally Advanced Nasopharyngeal Carcinoma: A Cross-Sectional Study

Curr Oncol. 2023 Jan 10;30(1):1000-1009. doi: 10.3390/curroncol30010076.

Authors

Yun Xu¹, Hewei Peng², Qiaojuan Guo^{1

3}, Lanyan Guo⁴, Xiane Peng^{2

5}, Shaojun Lin^{1

3}

Affiliations

¹ Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, China.
² Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350000, China.
³ Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou 350000, China.
⁴ School of Medical Imaging, Fujian Medical University, Fuzhou 350000, China.
⁵ Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350000, China.

Abstract

(1) Background: Prophylactic percutaneous endoscopic gastrostomy (PEG) maintained nutritional status and improved survival of patients with locally advanced nasopharyngeal carcinoma (LA-NPC). However, the role of PEG in patients’ quality of life (QoL) is still controversial. We aimed to investigate the effect of PEG on the QoL of patients with LA-NPC without progression. (2) Methods: Patients with LA-NPC between 1 June 2010 and 30 June 2014 in Fujian Cancer Hospital were divided into PEG and non-PEG groups. The QoL Questionnaire core 30 (QLQ-C30), incidence of adverse effects, weight, and xerostomia recovery were compared between the two groups of patients without progression as of 30 June 2020. (3) Results: No statistically significant difference in the scores of each QLQ-C30 scale between the two groups (p > 0.05). The incidence of xerostomia was higher in the PEG group than in the non-PEG group (p = 0.044), but the association was not seen after adjusting for gender, age, T, and N stage (OR: 0.902, 95%CI: 0.485−1.680). No significant difference in the incidence of other adverse effects as well as in weight and dry mouth recovery (p > 0.05). (4) Conclusion: PEG seems not to have a detrimental effect on long-term Qol, including the self-reported swallowing function of NPC patients without progressive disease.

Keywords: intensity-modulated radiotherapy; nasopharyngeal carcinoma; nutritional support; percutaneous endoscopic gastrostomy; quality of life.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma*
Cross-Sectional Studies
Gastrostomy / adverse effects
Humans
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms* / therapy
Quality of Life
Xerostomia* / etiology

Grants and funding

This work was funded by the Natural Science Foundation of Fujian Province, grant number 2019Y0061, the Training Program for Young and Middle-aged Backbone Talents of Fujian Provincial Health Care Commission, grant number 2020GGB013 and the Training Program for Young and Middle-aged Backbone Talents of Fujian Provincial Health Care Commission, grant number 2020GGA014, National Clinical Key Specialty Construction Program, and Fujian Provincial Clinical Research Center for Cancer Radiotherapy and Immunotherapy, grant number 2020Y2012.