To assess the aggressiveness of oral squamous cell carcinoma in the young population

J Pak Med Assoc. 2022 Oct;72(10):1937-1941. doi: 10.47391/JPMA.1771.

Abstract

Objectives: To assess the recurrence and disease-free survival in oral squamous cell carcinoma patients, and to compare them between two age groups.

Methods: Data were extracted from Patel hospital cancer registry database of patients admitted from January 1st2008 to December 31st 2018 based on retrospective diagnosed with oral squamous cell carcinoma. Patient stratified in to two groups i.e. patients with less than or more than 40 years. Various etiological factors, staging, treatment, site of the tumor and recurrence and mortality were assessed.

Results: Of the 450 patients, 124(27.5%) were in group A and 327(72.5%) were in group B. There were 101(81%) males in group A and 240(73.4%) males in group B. The overall mean age was 43.63±10.75 years (range: 22-70 years). The most common site of the tumour was cheek 232(51.5%). Recurrence of tumour was 45(36%) in group A and 120(37%) in group B (p=0.653). Overall mortality in group A was 67(54%) compared to 168(51%) in group B (p=0.811).

Conclusions: Mortality and disease recurrence in both age groups was almost the same. Cheek was the most common site of presentation.

Keywords: Oral cavity, SSC, Survival, Recurrence, Young age..

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell* / epidemiology
  • Carcinoma, Squamous Cell* / pathology
  • Carcinoma, Squamous Cell* / therapy
  • Female
  • Head and Neck Neoplasms*
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms* / epidemiology
  • Mouth Neoplasms* / pathology
  • Mouth Neoplasms* / therapy
  • Neoplasm Recurrence, Local / epidemiology
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Prognosis
  • Retrospective Studies
  • Squamous Cell Carcinoma of Head and Neck / pathology
  • Young Adult