Multifunctional nanoprobe for multi-mode imaging and diagnosis of metastatic prostate cancer

Ze Wang; Annan Liu; Xingchen Li; Lin Guan; Huiyuan Xing; Liang He; Linan Fang; Andrei V Zvyagin; Xiaoyu Yang; Bai Yang; Quan Lin

doi:10.1016/j.talanta.2023.124255

Multifunctional nanoprobe for multi-mode imaging and diagnosis of metastatic prostate cancer

Talanta. 2023 May 1:256:124255. doi: 10.1016/j.talanta.2023.124255. Epub 2023 Jan 10.

Authors

Ze Wang¹, Annan Liu¹, Xingchen Li¹, Lin Guan¹, Huiyuan Xing¹, Liang He², Linan Fang³, Andrei V Zvyagin⁴, Xiaoyu Yang⁵, Bai Yang¹, Quan Lin⁶

Affiliations

¹ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, PR China.
² Department of Urology, The First Hospital of Jilin University, Changchun, 130021, Jilin, PR China. Electronic address: lianghe9278@jlu.edu.cn.
³ Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, 130000, PR China. Electronic address: fanglinan_jdyy@jlu.edu.cn.
⁴ Australian Research Council Centre of Excellence for Nanoscale Biophotonics, Macquarie University, Sydney, NSW, 2109, Australia; Australia and Institute of Biology and Biomedicine, Lobachevsky Nizhny Novgorod State University, 603105, Nizhny Novgorod, Russia.
⁵ Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, 130041, PR China.
⁶ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, PR China. Electronic address: linquan@jlu.edu.cn.

PMID: 36652761
DOI: 10.1016/j.talanta.2023.124255

Abstract

The high incidence and complex subtypes of prostate cancer put forward higher requirements for accurate diagnosis. Furthermore, advanced prostate cancer is prone to metastasis. Single biological imaging mode faces a challenge of sensitive and fast bioimaging of metastasic prostate cancer. Thus, exploring a nanoprobe with multi-mode imaging function has an important impact on preoperative imaging and intraoperative visualization guide of metastatic prostate cancer. Herein, based on the optical properties and X-ray attenuation capability of Au nanodots as well as the slow electronic relaxation of Gd³⁺, we designed and fabricated the multifunctional nanoprobe Au/Gd nanodots for multi-mode imaging and accurate diagnosis of bone metastatic prostate cancer. The results showed that multiple imaging modes complement each other to achieve high-precision of metastasic prostate cancer detection and accurately guide treatment. In addition, in vitro/vivo experiments showed that Au/Gd nanodots had good biocompatibility and biosafety. Therefore, the prepared multifunctional nanoprobe may provide new strategies and insights for precise diagnosis of metastatic prostate cancer in clinical practice.

Keywords: Multi-mode imaging; Nanoprobe; Precise diagnosis; Prostate cancer.

MeSH terms

Humans
Magnetic Resonance Imaging / methods
Male
Prostatic Neoplasms* / diagnostic imaging
Tomography, X-Ray Computed* / methods