HIV/AIDS Curability Study, Different Approaches and Drug Combination

Infect Disord Drug Targets. 2023;23(4):e170123212803. doi: 10.2174/1871526523666230117115826.

Abstract

Aim: HIV infection is currently an incurable disease characterized by life-long drug utility. Its incurable causality and mechanism are still unknown to us.

Methods: To overcome this therapeutic setback, some breakthroughs should be made by utilizing different approaches. How to plan some experimental and clinical novelty for HIV curability is a modern challenge. In this article, new ideas and approaches for global HIV/AIDS therapeutic strategies are proposed and represented by scientific insights.

Results: Pharmaceutical characteristics, herbal medicine, novel drug targets, cutting-edge biotherapy, drug combination, animal modalities, and immune-stimuli for HIV latency, as well as clearance, are highlighted.

Discussion: To elucidate our understanding of curative treatment for HIV/AIDS, many new pathological discoveries, expansion, technical advances, and potential drug targets are constructed. After the discovery of novel pathogenesis and therapeutic evolution, HIV/AIDS therapeutic curability may become achievable and a reality.

Conclusion: Transformation from animal model investigation to widespread therapies for larger volume of human population is a necessity in modern medicine. In this infectious treatment scenario, major breakthroughs in medicine and drug development are anticipated.

Keywords: HIV infection; biological therapy; curative target; human genome; human immunity; viral reservoir; virus latency.

MeSH terms

  • Acquired Immunodeficiency Syndrome* / drug therapy
  • Animals
  • Antiretroviral Therapy, Highly Active
  • Drug Combinations
  • Drug Delivery Systems
  • HIV Infections* / drug therapy
  • Humans

Substances

  • Drug Combinations