NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distinct from other INHATs. In this review, we summarize the biological function of NOC2L in histone acetylation regulation, P53-mediated transcription, ribosome RNA processing, certain development events and carcinogenesis. We propose that NOC2L may be explored as a potential biomarker and a therapeutic target in clinical practice.
Keywords: Carcinogenesis; Embryonic development; Inhibitor of histone acetyltransferase (INHAT); NOC2 like nucleolar associated transcriptional repressor (NOC2L); P53; Transcriptional regulation.
© 2023. The Author(s).