Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase

J Transl Med. 2023 Jan 17;21(1):31. doi: 10.1186/s12967-023-03877-2.

Abstract

NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distinct from other INHATs. In this review, we summarize the biological function of NOC2L in histone acetylation regulation, P53-mediated transcription, ribosome RNA processing, certain development events and carcinogenesis. We propose that NOC2L may be explored as a potential biomarker and a therapeutic target in clinical practice.

Keywords: Carcinogenesis; Embryonic development; Inhibitor of histone acetyltransferase (INHAT); NOC2 like nucleolar associated transcriptional repressor (NOC2L); P53; Transcriptional regulation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Histone Acetyltransferases* / antagonists & inhibitors
  • Histone Acetyltransferases* / metabolism
  • Histones* / metabolism
  • Repressor Proteins* / genetics
  • Transcription Factors / genetics

Substances

  • Histone Acetyltransferases
  • Histones
  • Repressor Proteins
  • Transcription Factors