Discovery of (E)-2-Methoxyethene-1-sulfonyl Fluoride for the Construction of Enaminyl Sulfonyl Fluoride

Min Liu; Wenjian Tang; Hua-Li Qin

doi:10.1021/acs.joc.2c02836

Discovery of (E)-2-Methoxyethene-1-sulfonyl Fluoride for the Construction of Enaminyl Sulfonyl Fluoride

J Org Chem. 2023 Feb 3;88(3):1909-1917. doi: 10.1021/acs.joc.2c02836. Epub 2023 Jan 17.

Authors

Min Liu¹, Wenjian Tang², Hua-Li Qin¹

Affiliations

¹ School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
² School of Pharmacy, Anhui Medical University, Hefei 230032, China.

PMID: 36649643
DOI: 10.1021/acs.joc.2c02836

Abstract

A new sulfonyl fluoride reagent (E)-2-methoxyethene-1-sulfonyl fluoride (MeO-ESF) was developed and successfully applied for the construction of enaminyl sulfonyl fluoride (N-ESF). This protocol provides highly atom-economical access to diverse N-ESF and produces CH₃OH as the sole byproduct under mild and environmentally benign conditions.