Oral microbiota have a complex impact on the host's health and disease states. It has been found that the composition of lung flora bears a striking resemblance to the composition of oral flora. Moreover, oral pathogenic bacteria have been detected in the sputum and bronchoalveolar lavage fluid of patients with chronic obstructive pulmonary disease (COPD), suggesting that oral microbiota play an important role in the pathogenesis and development of COPD. Findings from lots of studies have shown that oral microbiota may participate in the pathogenesis and development of COPD through non-specific immune response, specific immune response, and the activities of protein hydrolase. Herein, we mainly summarized the available evidence on the relationship between oral microbiota and COPD. By examining the relationship between the two, we elaborated on the application of oral microbiota in the diagnosis and prevention of COPD, discussed possible directions for future research, and provided references for developing new therapeutic approaches.
口腔微生物对宿主的疾病健康状态有着复杂的影响。研究发现肺部的菌群组成与口腔的菌群组成高度相似，且在慢性阻塞性肺疾病患者的痰液、支气管灌洗液中检测出口腔致病菌，提示口腔微生物在慢性阻塞性肺疾病的发生发展中发挥重要作用。大量研究结果表明， 口腔微生物可能通过非特异性免疫反应、特异性免疫反应、蛋白水解酶的作用等途径参与慢性阻塞性肺疾病的发生发展。本文主要总结了口腔微生物与慢性阻塞性肺疾病之间关系的现有证据，通过研究两者之间的关系，阐明口腔微生物在诊断和预防慢性阻塞性肺疾病中的应用，探索未来可能的研究方向，为开发新的治疗方法提供参考。
Keywords: Chronic obstructive pulmonary disease; Oral microbiota; Periodontitis.
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